The research environment of the Center is multi-institutional involving faculty and collaboration across multiple departments in the Johns Hopkins Bloomberg School of Public Health, the School of Medicine, and other institutions.  Research activities include the design, conduct, and analysis of clinical trials; performance of systematic reviews and meta-analysis of  the research evidence; methodological work, such as studies of bias in study design and dissemination of results;  and examination of the language and nomenclature of trials.

The subject matter of the clinical trials and systematic reviews conducted by the Center covers a variety of health conditions including but not limited to the ocular complications of AIDS, uveitis, non-arteritic anterior ischemic optic neuropathy, Alzheimer's disease, childhood asthma, emphysema, Barrett's esophagus, non-alcoholic steatohepatitis, and dysfunctional uterine bleeding.

Listed below are current or recent research studies:

Ongoing:

• Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT)
• American Lung Association - Asthma Clinical Research Center (ALA-ACRC)
• United States Cochrane Center (USCC)
• Cochrane Collaboration Eyes and Vision Group (CEVG)
• Depression in Alzheimer's Disease Study - Phase 2 (DIADS-2)
• Multicenter Uveitis Steroid Treatment Trial (MUST)
• Preservation of Vascular Access Study (PVAS)
• The Studies of Ocular Complications of AIDS (SOCA)
• Sleep Heart Health Study (SHHS)
• TrialsCentral™ - Your source for online clinical trials information (TrialsCentral)

Data Collection Completed:

• A+ Asthma Early Intervention for Asthma Management (A+ Asthma)
• Chemoprevention Barrett's Esophagus Trial (CBET)
• The Ischemic Optic Neuropathy Decompression Trial (IONDT)
• Surgical Treatments Outcomes Project for Dysfunctional Uterine Bleeding (STOP-DUB)
• Wegener's Granulomatosis Etanercept Trial (WGET)